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treatment of suture granuloma

Hypersensitivity reactions to bovine collagenresult in induration and erythema in the area where the collagen has been injected. Aluminium can be introduced into the body through vaccines and immunotherapy. Other types of foreign body granuloma may persist for decades. Granuloma annulare is a benign skin condition characterized by small, raised bumps that form a ring with a normal or sunken center. "Suture granulomas can resolve on their own, and simply monitoring it or using an anti-inflammatory agent may be all that's needed," says Dr. Mamelak, our dual board-certified dermatologist. Cutaneous sarcoidosis may be part of a systemic granulomatous disease that usually affects middle-aged black women. Introduction. DOI: 10.1016/j.bjps.2011.07.033. 137. Granulomas are not cancerous. It commonly occurs several years after various types of surgeries [ 1 ]. The procedure was performed in the operating room under standard aseptic procedures. This material may not be published, broadcast, rewritten or redistributed in any form without prior authorization. Granuloma annulare is a skin condition that causes bumps underneath the skin. Suture Granuloma With False-Positive Findings on FDG-PET/CT Resected via Laparoscopic Surgery. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, tends to affect children more than adults, https://radiopaedia.org/articles/granuloma?lang=us, https://www.stopsarcoidosis.org/what-is-sarcoidosis/causes-risk-factors/, https://www.crohnscolitisfoundation.org/what-is-crohns-disease/causes, https://rarediseases.org/rare-diseases/granuloma-annulare/, https://medlineplus.gov/granulomatosiswithpolyangiitis.html, https://dermnetnz.org/topics/granuloma-annulare/, https://www.crohnscolitisfoundation.org/what-is-crohns-disease/overview, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192066/, https://www.stopsarcoidosis.org/what-is-sarcoidosis/, https://www.ncbi.nlm.nih.gov/books/NBK554586/. (The author explains the biology of facial fillers, including the biology of phagocytosis and granulomatous inflammation. Although keloids may be painful, the pain usually is not associated with menses, and the lesions do not bleed. Dermatol Surg. Infect. In addition to antibiotic treatment, canthotomy and wide drainage for orbital cellulitis and necrotizing fasciitis may require surgical debridement of involved tissue as well as consideration for hyperbaric oxygen. Your healthcare provider may recommend corticosteroids, isotretinoin (Absorica, Zenatane) or tacrolimus (Protopic). Silicone granulomas can form in the dermis when trauma causes the capsule around asilicone implantto rupture. Suture granuloma usually develops slowly after an intervention. To be considered for publication, submissions must meet these guidelines. 1. 05/02/2018 10:45. The condition has a range of cutaneous presentations, including patches, plaques, and nodules. For wood splinters, cactus spines, and suture material, the granulomas tend to be isolated and so can often be treated by biopsy or small excision. 25. 426-34. A suture granuloma resistant to antibiotics is treated with surgical excision, accomplished internally. (In this review, the author discusses the various modalities available for identification of cutaneous foreign bodies. Note that this may not provide an exact translation in all languages, Home They tend to go away on their own. Background 409-17. This is a granulomatous condition of the skin caused or worsened by a dog compulsively licking a specific spot on their body until a granuloma develops; Juvenile cellulitis (puppy strangles) Laser hair removal can be attempted to treat pilonidal sinuses and hair granulomas in barbers, with excision as definitive treatment of recurrent or recalcitrant lesions. The development of foreign body granulomas is thought to be under the control of both the humoral and cell-mediated immune system pathways and most likely represents a type IV hypersensitivity reaction to a foreign antigen. This is especially true if they come up at the site of a previously treated skin cancer. Three surgical methods for suture removal were performed under local anesthesia. 64. In around 90% of people with the condition, lumps grow in the lungs. They typically present in the months following a trauma or procedure, as the wound heals. Larger nodules, ulcers and sclerosis may slowly develop, months to years after the injury. We present a case of caecum suture granulomas in a 45-year-old man which was clinico-radiologically misdiagnosed as colon carcinoma. (In this review, the author discusses treatment options for complications arising from injectable fillers. The laser instrument ablates (removes) the tissue by vaporizing the surface layers. When they occur, the time to presentation has varied from within a few months to more than 50 years. six Cytokines help to activate fibroblasts, which will make collagen, trigger endothelialization, and help with the formation of new blood vessels, a . Small Skin Incision Method Foreign material may be introduced intentionally (such as tattoos of cosmetic fillers) or accidentally (such . For a granulomatous reaction to hyaluronic acid, intralesional hyaluronidase or extrusion using a #11 blade could be considered before corticosteroids, although caution should be taken with injecting hyaluronidase into actively inflamed areas. The initial response to most foreign materials is the recruitment of neutrophils to the site. Copyright 2023 American Academy of Family Physicians. Dr. Zahid Niazi answered Cosmetic Surgery 40 years experience Likely yes: Depends - anytime the suture is exposed and within an infected granuloma, it is best to remove it as the half life of the current day dissolvable sutu. 32. Pyogenic granuloma (PG) is a benign vascular proliferation occurring on the skin or subcutaneous tissue and arises at the sites of trauma, infection, foreign body reactions, or delayed wound healing.1 Paronychia often appears in the hallux, where periungual PG is unpredictable. In most cases, skin granulomas will go away on their own without treatment. Natural materials, such as gut, are more likely to 'spit' than monofilament nylon. The presentation of a suture granuloma post-herniorrhaphy can include urinary symptoms (especially if it has a paravesical location) or a suprapubic mass.3 Suture granuloma can also present as a paravesical abscess with swelling and tenderness at the groin area. 1984. pp. - And More, (In this comprehensive review, the authors discuss the most commonly used fillers, the most common adverse reactions, as well as the characteristic histopathologic findings that allow the identification of the injected filler agent. Register for free and gain unlimited access to: - Clinical Updates, with personalized daily picks for you Schmidt R, Choudhry O, Takkellapati R, Eloy J, Couldwell W, Liu J. Hermann Schloffer and the Origin of Transsphenoidal Pituitary Surgery. 2006;47 (5): 748-51. Sometimes, though, they might come. You will need to go back to the hospital for around 4 weeks, 1 day each week to have the treatment repeated. They can develop anywhere on the body, including the skin, lungs, and other organs. Conclusion: In addition to tumor. High-frequency (>10 MHz) linear probe is useful. Welcome to Sanova Dermatology, your premier source for cosmetic, medical, and surgical dermatology. Granuloma treatments. Treatment Following informed consent patient underwent excision of the suture granuloma with reconstruction of the ocular surface with amniotic membrane under local anaesthesia ( figure 2 ). Suture granulomas, also known as Schloffer tumors, are localized inflammatory reactions in response to retained suture material. It depends on the type of granuloma. Chung YE, Kim EK, Kim MJ et-al. However, these growths can also appear where dissolvable or absorbable suture material has been used under the skin to repair a wound. Suture granulomas can also form over the site of permanently implanted medical materials such as fixators, mesh, or other surgical devices. Other medical options used to treat foreign body granulomas include: The natural history of foreign body granuloma varies depending on the cause. Arch Dermatol. A collection of Photo Quiz published in AFP is available at https://www.aafp.org/afp/photoquiz. Electron microscopic documentation of late changes in permanent fillers and clinical management of granulomas in affected patients. Too many sutures and knots with a larger caliber of suture may increase the risk of suture reactivity, which may cause postoperative complications, such as abscess, granuloma or fistula at the . For example, people with chronic granulomatous disease may be given antibiotics and other treatments to try to prevent further infections. Scientists do not know what causes Crohns disease. A 45-year-old female asked: Can granulomas diseases go way without treatment? Ultrasound is often used as a first-line imaging modality. This study confirms that polarizable material within a cutaneous granuloma does not exclude a diagnosis of systemic sarcoidosis and, in fact, polarizable foreign material is not uncommon in the cutaneous lesions of these patients. 23. Rheumatology 54 years experience. . Lung nodules are small growths on the lungs. If you have any concerns with your skin or its treatment, see a dermatologist for advice. Sometimes, long-term conditions such as Crohns disease and sarcoidosis can cause granulomas. An important clue is that these lesions occur in an arrangement localized to the area of inoculation (Figure 1); however, as is the case with silicone, the foreign material may migrate, leading to granulomas at sites distant from the area of implantation. Suture granulomas result from granulomatous inflammation induced by suture material, with nonabsorbable sutures being more likely to cause this reaction. They less commonly occur with absorbable sutures, but may still occur. Surgical excision is effective in patients who do not improve with topical medication. Pyogenic granuloma (PG) is a common benign vascular proliferation. London: Mosby Elsevier, 2008. 6, Bee Cave, TX 78738 - (512) 366-8568, 701 Metairie Road, Metairie, LA 70005 - (504) 836-2050, 3434 Prytania St., New Orleans, Louisiana 70115 - (504) 897-5899, 111 Veterans Boulevard, Metairie, LA 70005 - (504) 838-8225, 1900 Saint James Place, Houston, TX 77056 - (713) 850-0240, 12319 North Mopac Expressway, Austin, Texas 78758 - (512) 837-3376, 3705 Medical Parkway, Austin, Texas 78705 - (512) 454-3781, 13830 Sawyer Ranch Road, Dripping Springs, TX 78620 - (512) 829-0009, 1601 E. Pflugerville Parkway, Pflugerville, Texas 78660 - (512) 252-3700, 5145 North FM 620 Rd, Austin, Texas 78732 - (512) 266-0007, Dripping Springs Clinical Research Trials, eliminate the foreign material through the skins surface. Become a Gold Supporter and see no third-party ads. Scar revision of the abdominal wall. Treatment options for cutaneous pyogenic granulomas: a review. 3. However, if the growth is painful, continues to grow, or is an aesthetic concern, the suture (and granuloma) can simply be removed. Journal of plastic, reconstructive & aesthetic surgery. Suture granuloma treatment. The rash occurs most commonly on the hands, feet, wrists and ankles of young adults. No sponsor or advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC. Dermatology [2 volumes], 2nd edn. Other presentations include sinus tracts and abscesses. At the time the article was created Matt A. Morgan had no recorded disclosures. T cells and fibroblasts also participate in this inflammatory response [3]. Enjoying our content? Granulomas Thank you for your photos, to really make recommendations one would need a proper exam. Involuntary causes of foreign body granulomas, such as minerals and metals accidentally imbedded in the skin, are often seen in those who work in construction industries [3]. Treatment options include: Medications. Granuloma annulare may be skin-colored in skin of any color; it may appear pink, light brown, red-brown, or light purple in lighter skin colors; or it may be pink, brown, or . Subcutaneous liquid silicone injections may also result in cutaneous nodules and indurated or ulcerated plaques. Intralesional injections should be given approximately every 4 weeks. The treatment options range from only observation, simple excision of the tissue and the suture with a No.10 scalpel blade, electrocauterisation or application of hot compress 3-4 times a day for skin . Choices include corticosteroids, cyclosporine, and minocycline. (In this review, the authors discuss the distinguishing clinical and histopathologic findings in various epithelioid granulomas, including zirconium and beryllium granuloma. People will often find a clear liquid leaking from the lumps before they crust over. Granulomas can also form around a permanently placed medical device. Reported sites include the umbilicus of infants, amputation stumps, injection sites and the inguinal area. It is generally a tender, erythematous nodule that occurs several days to weeks after surgery. The rash borders are circular or semicircular, with a diameter up to 2 inches (5 centimeters). 35. Foreign body granulomas (2016). They are most often tender erythematous nodules. Treating Umbilical Granulomas In most cases, treating granulomas is simple. Some foreign body reactions (ie, those due to keratin, suture, tattoo ink, paraffin, bovine collagen, and hyaluronic acid, among others) have a distinctive pathology. Granulomas are a rare side effect of insulin injections containing zinc. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. This can happen on the skin or inside the body. Takeshita N, Tohma T, Miyauchi H et-al. Requena, L, Requena, C, Christensen, L, Zimmermann, US, Kutzner, H, Cerroni, L. Adverse reactions to injectable soft tissue fillers. Clinical photographs taken at each appointment can also be helpful in determining if the patient is responding to treatment. They are a rare surgical complication that is sometimes radiologically challenging to diagnose, especially if the intra-abdominal is communicating with the anterior abdominal wall. Complications of foreign body granuloma can include: Clinical history and examination are often adequate to diagnose foreign body granuloma. 2001. pp. Additional symptoms may include: oozing. 2011. pp. If foreign bodies are present on the surface of the skin (such as debris in a wound), keratinocytes migrate along the connective tissue formed by fibrin, fibronectin and type V collagen, and dissect it from the underlying tissue during the proliferative phase of healing. In addition, some endogenous materials, such as keratin and urate crystals, can induce a foreign body granuloma, and in these situations, there will not be a history of inoculation. The differential diagnoses include: Foreign body granulomas can be excised. A biopsy of the lesion confirms the diagnosis. Your cells begin to cluster as they completely surround the material or the general area of where it was removed. Sometimes it is associated with diabetes or thyroid disease. Jun 4, 2010. For wood splinters, cactus spines, and suture material, the granulomas tend to be isolated and so can often be treated by biopsy or small excision. You can learn more about how we ensure our content is accurate and current by reading our. If a patient is being actively treated for a foreign body granuloma, frequent follow-up is recommended to monitor for response to the treatment. ), (The various lasers available for tattoo removal, as well as the recommended procedure protocol, are reviewed. Keloids are common, benign neoplasms consisting of increased fibroblasts and collagen that may occur after a trauma or surgical procedure. This is the most common type of granuloma annulare. ), Kilmer, SL. DermNet New Zealand Editor in Chief: Hon A/Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand. They include: When something penetrates the skin, eye, or other parts of the body, it can lead to a foreign body granuloma. 6. They present as sterile furuncles (boils), which later heal with atrophic scarring at the injection site. Close follow-up will allow the clinician to appreciate even small interval changes in the patients condition. This study confirms that polarizable material within a cutaneous granuloma does not exclude a diagnosis of systemic sarcoidosis and, in fact, polarizable foreign material is not uncommon in the cutaneous lesions of these patients. Quiz yourself on Granulomas 9 Questions available Tuberculosis: Pathology review Abnormal lumps and bumps can be concerning, especially when they develop on the incision line after skin cancer surgery. However, the lesions typically are not painful and do not bleed. This series is coordinated by John E. Delzell Jr., MD, MSPH, associate medical editor. The treatment of choice is resection of the retained suture and surrounding inflammatory tissue. Some people with a granuloma need treatment, buts others may not. Other methods of removal depend on the cause. Before long, it . In particular, patients that demonstrate hypersensitivity to bovine collagen are at an increased risk of developing foreign body granulomas at injection sites and so it is recommended that skin testing be performed by injecting 0.1mL of bovine collagen into the forearm of the patient and waiting for at least 30 days before injecting the desired site. Suture granulomas can occur right after surgery or, in the case of permanent devices, later on when the immune system delays its defense against the foreign object. In those situations where an endogenous material is the cause of the granuloma, look for evidence of an underlying skin condition such as pseudofolliculitis barbae (PFB), acne keloidalis nuchae (AKN), an ingrown nail, the punctum of an epidermoid cyst, or a characteristic pilonidal sinus (cyst). While its important to visit a dermatologist about any unexplained growths that have suddenly appeared, it can be helpful to know that not all bumps indicate a serious problem. This may include: Ceasing drug triggers Careful oral hygiene Dental treatment of oral trauma caused by teeth Removal of adjacent piercings. A foreign body granuloma forms when the host immune system is unable to digest the foreign body, resulting in the accumulation of macrophages and histiocytes. DermNet provides Google Translate, a free machine translation service. A granuloma is not cancerous or life-threatening. In these cases, individuals should be referred to the appropriate caregivers for psychological counseling. This content is owned by the AAFP. Methods: The case reported here was a 22-year-old female who presented with right iliac fossa . Facial Plast Surg. DermNet does not provide an online consultation service.If you have any concerns with your skin or its treatment, see a dermatologist for advice. Some centers have access to more sophisticated procedures to help identify the exact nature of a foreign body. biopsy specimens showed granulomatous cutaneous involvement. The image at right is after three months of appropriate treatment, without surgery. Gilardino MS. 1991. pp. Picosecond lasers have also been used. Things that can lead to foreign body granulomas include: There are a few different types of skin granulomas. Laser treatment of tattoos. Sometimes, granulomas can develop inside the body. Essentially, the granulomatous response is an attempt by the body to wall off the foreign material. It is possible that a lump or granuloma may form as a reaction to suture material used in eyelid surgery. As macrophages surround and isolate the foreign body, some of them will fuse to form multinucleated giant cells. When the silver nitrate pencil/or stick is pressed gently on the granuloma, it creates a very mild chemical burn, reducing the size of the granulomas and it may even eliminate them completely. Granulation tissue is the primary type of tissue that will fill in a wound that is healing by secondary intention. Can poor sleep impact your weight loss goals? Typically, they are diagnosed by palpation because they are more prominent with increased abdominal pressure and may be reduced with external pressure. Since many of the treatment recommendations for foreign body granulomas are anecdotal or based on small case series, the exact time frame to expect results, and switch therapy if a patient is unresponsive, is quite subjective. Rettenbacher T, Macheiner P, Hollerweger A et-al. Skin-nontumor: Foreign body reaction PathologyOutlines.com, Books about skin diseasesBooks about the skin Even with a negative skin test, some patients have developed granulomas at the site of cosmetic injection. Some people may experience lumps on more than one part of the body at a time. Sometimes, though, they might come back. The most common presentation is a reddish-brown nodule in a previous scar. Find out more about chronic granulomatous disease treatment here. Immune system cells cluster around the foreign body or the site where a foreign body has been removed, encapsulating the area with immune cells. and from discussions with other ophthalmologists and general surgeons that suture reactions of delayed and prolonged granuloma formation after the use of catgut suture material have increased alarmingly. "Suture granulomas can resolve on their own and simply monitoring it or using an anti-inflammatory agent may be all that's needed," says Dr. Mamelak. For foreign body granulomas that do not spontaneously resolve (tattoo ink, paraffin, silicone, poly(methyl methacrylate) [PMMA], poly(hydroxyethyl methacrylate), poly-L-lactic acid, calcium hydroxylapatite, keratin, and urate crystals), observation is not an option if the patient desires resolution. This is the immune systems way of stopping the Mycobacterium tuberculosis bacteria from spreading to other parts of the body. #2. The editors ofAFPwelcome submissions for Photo Quiz. 2012;33(2):E5. Sorry, no locations are in this area. The granuloma can look red and swollen in some cases. (The various lasers available for tattoo removal, as well as the recommended procedure protocol, are reviewed. {"url":"/signup-modal-props.json?lang=us"}, Morgan M, Bell D, El-Feky M, et al. - Drug Monographs It is generally a tender, erythematous nodule that occurs several days to weeks. Prescription-strength products may help clear the skin faster. Answer: Wound treament post surgery. 1997. pp. If it is determined you have a suture granuloma, there are a number of treatment options available. A granuloma is a histological term for a collection of histiocytes or epithelioid histiocytes accompanied by a range of multinucleated giant cells (masses of macrophages) and other inflammatory cells [1]. It has been proposed that sarcoidosis occurs when a genetically susceptible person is exposed to an environmental antigen. Communications through our website or via email are not encrypted and are not necessarily secure. ), Hirsch, BC, Johnson, WC. A foreign body granuloma is a manifestation of the skins immune system, which defends against non-self materials. Vigilance must be maintained in patients presenting with foreign body granulomas to identify the occasional associated systemic disease such as sarcoidosis (see above), or the much more rare berylliosis, which can occur after occupational inhalation of beryllium. History of accidental, intentional, or iatrogenic introduction of an exogenous foreign material into the body at the site of the reaction is a very helpful clue to the diagnosis; although, because of the delayed onset of this condition, some patients may not recall the inciting event. In other cases, where the growth continues to get worse or becomes painful, the suture and granuloma can both be removed. Once the diagnosis is confirmed, there are a variety of ways to treat suture granulomas. 2011 Sep 1;64(9):1216-20. 2-15. It may be confused with a tumor or a recurrent tumor after surgery and should be considered in the differential in the correct setting. Int Surg. the presence of sticky mucus. Granulomatosis with polyangiitis. Another type of light therapy, laser treatments, can also be helpful. Author: Joel Winders, medical student, University of Auckland, Department of Dermatology, Waikato Hospital, Hamilton, New Zealand. arrow-right-small-blue After a varying amount of time (days, weeks, months, or years) a chronic inflammatory reaction occurs that persists. Direct hernias often do not cause overlying cutaneous change. 2015 Jul 31;33(3):497523. Lick Granuloma Bandage. A nodule may form at the site of intralesional corticosteroid injection, due to incomplete absorption or unusual dispersion of the injected material. For a facial location, a class 3 or 4 topical steroid such as mometasone or triamcinolone 0.1% could be used for 3 to 4 weeks; the treatment could then be switched to a class 6 steroid such as desonide or alclometasone. Hypothyroidism has played a role in some cases of acral lick granuloma, especially in Black Labs. The tophi themselves can be excised. This article will explain what a granuloma is, how and why they develop, and how to treat them. A rare disease in canines associated with unusual reactions to insect bites; Lick granuloma. alcian blue pH 2.7 or colloidal iron), Polymethylmethacrylate (PMMA) with bovine collagen (Artefill/Artecoll/Arteplast), Uniform round nonbirefringent bodies in cystic spaces, Poly(hydroxyl)ethylmethacrylate with hyaluronic acid (DermaLive/DermaDeep), Irregular polygonal, pink, nonbirefringent particles that resemble broken glass in cystic spaces, Irregular fusiform, oval and spiky birefringent particles in cystic spaces that resemble suture material, Calcium hydroxylapatite (Radiance/Radiesse), Polyvinylpyrrolidone-silicone suspension (Bioplastique), Irregular cystic spaces containing translucent jagged popcorn nonbirefringent particles, Papule with a central black dotBirefringent material with polarized lightStain with PAS, In setting of pseudofolliculitis barbae, acne keloidalis nuchae, ruptured epidermoid cysts, ingrown nails, and pilonidal sinusesVariably birefringent keratin flakes or hair shaftsStain with acid-fast stains, Immunohistochemical staining with anti-keratin antibodies, Birefringent material with polarized lightStain with PAS, Nodules within a surgical scar or an inflamed wound that can develop a fistulaBirefringent fibers with polarized light, Nodules at joints or ear helicesAmorphous pink material in formalin-fixed tissue, Alcohol-fixed tissue preserves the birefringent crystals that stain with silver stains, Pulsed carbon dioxide laser (Q-switched laser is contraindicated for tattoos with granulomatous reactions), Minocycline or doxycycline 100mg once to twice daily with or without celecoxib 200mg twice dailyIsotretinoin 20mg daily for 6 months, CorticosteroidsTacrolimus 0.1% twice daily, Corticosteroids up to 60mg/dayCyclosporine up to 5mg/kg/day, Observation (usually resolves as material degrades), Corticosteroids 2.5-10mg/mLHyaluronidase 150U/mL (0.5mL combined with 1.5mL of 1% lidocaine with epinephrine)not into inflamed lesions, Corticosteroids up to 60mg/dayMinocycline 250mg twice daily for one week, Corticosteroids 2.5-10mg/mL in anesthetic solution5-fluorouracil (0.9mL of 5-FU 50mg/mL mixed with 0.1mL of triamcinolone 10mg/mL) given in 0.05mL aliquots every 2-4 weeks, Corticosteroids 2.5-10mg/mL5-fluorouracil (250mg/mL 5-FU mixed with triamcinolone 10mg/mL and 1mL of 1% lidocaine) injected with 27-G needle every 2-4 weeks, Allopurinol 200-600mg daily for average of one year, CorticosteroidsIbuprofen 1800-2400mg dailyAllopurinol 400mg dailyMinocycline 200mg dailyHydroxychloroquine 6mg/kg daily, Avoid lip area for injections (increased risk of nodules), Wood splinter/cactus spine/arthropod parts, For pseudofolliculitis barbae (PFB) and acne keloidalis nuchae (AKN), retinoids, glycolic acid, and/or clindamycin, For PFB, AKN, and pilonidal sinus, laser hair removal with long-pulsed lasers (alexandrite, 810nm diode or Nd:YAG), For PFB and AKN, avoid shaving or, if clean-shaven look desired, shave everyday in the direction of hair growth and lift any ingrowing hairs prior to shaving, Observation for spontaneous extrusion of suture.

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treatment of suture granuloma